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FLASH GENE
Symbol CHRDL2 contributors: mct/npt - updated : 03-12-2009
HGNC name chordin-like 2
HGNC id 24168
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three VWFC domains, with SD1 from VWC1 and VWC3 confering BMP affinity and specificity to the protein (Fujisawa 2009)
  • a hydrophobic N-terminal signal sequence and a cleavage site
  • cysteine-rich repeats specific of several extracellular matrix proteins
  • a signal peptide and three CR domains
  • three chordin-like cysteine-rich repeats domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Chrdl2
    intraspecies paralog to CHRDL1
    Homologene
    FAMILY
  • chordin family
  • bone morphogenetic protein (BMP) superfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • key developmental protein dorsalizing early vertebrate embryonic tissues by binding to ventralizing TGFB family bone morphogenetic proteins (BMPs)
  • playing a role during myoblast and osteoblast differentiation (Oren 2004)
  • with chordin, and BMPER, regulate BMP2 signaling by different recognition mechanisms (Zhang 2007)
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding activin A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast, lung and colon cancer
    constitutional     --over  
    in osteoarthritic joint cartilage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS