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FLASH GENE
Symbol SECISBP2 contributors: mct/npt - updated : 26-02-2009
HGNC name SECIS binding protein 2
HGNC id 30972
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative RNA-binding domain
  • C-terminal domain involved in SECIS binding, ribosome binding and Sec incorporation
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • is essential for the cotranslational insertion of sec into selenoproteins
  • may be involved in preventing termination at the UGA/sec codon
  • remains ribosome bound except during selenocysteine delivery to the ribosomal A-site
  • protein of the Sec incorporation machinery, having transcription and translation regulated in a coordinated manner in response to stress (Papp 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • EIF4A3 interaction with the selenoprotein mRNA prevents the binding of SECISBP2, which is required for selenocysteine insertion, thereby inhibiting the synthesis of the selenoprotein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) THMD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS