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FLASH GENE
Symbol PVALB contributors: mct - updated : 03-06-2015
HGNC name parvalbumin
HGNC id 9704
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Pva
homolog to C.elegans F36H12.16
Homologene
FAMILY
  • parvalbumin family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in muscle relaxation
  • its expression levels could influence GABA synthesis
  • skeletal muscle Ca(2+) binding protein, that facilitate myocardial relaxation
  • acts as a unique "delayed" Ca(2+) buffer and facilitates Ca(2+) sequestration from cytosol
  • Ca(2+) buffer and Ca(2+) transporter/shuttle protein that may also play an additional role in Mg(2+) handling
  • cortical GABAergic interneurons expresses PVALB and plays a critical role in the control of pyramidal neuron excitability and the generation of cortical gamma frequency oscillations
  • PVALB-interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus
  • CALB1, CALB2, PVALB, regulate presynaptic inner hair cells (IHCs) function for metabolically efficient sound coding
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for Gitelman's syndrome for SLC12A3-negative cases (Riviera-Munoz 2008)
    Marker
    Therapy target
    ANIMAL & CELL MODELS