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FLASH GENE
Symbol MESP1 contributors: mct - updated : 02-08-2012
HGNC name mesoderm posterior 1 homolog (mouse)
HGNC id 29658
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a basic helix-loop-helix dimerization domain
  • a unique CPXCP motif
  • a 2-repeat GQ region between the N- and C-terminal domains
  • HOMOLOGY
    interspecies homolog to rattus Mesp1 (67 pc)
    homolog to murine Mesp1 (67.6 pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • potentially playing an important role in the development of the nascent mesoderm including primordial germ cells
  • playing a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm
  • definings the rostrocaudal patterning of the somites by participating in distinct Notch pathways
  • cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis
  • has a significant role in the epithelialization of somitic mesoderm
  • a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells
  • involved in cardiovascular differentiation through DKK1-mediated blockade of Wnt-signalling
  • acts as a key regulatory switch during cardiovascular specification, residing at the top of the hierarchy of the gene network responsible for cardiovascular cell-fate determination
  • coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating embryonic stem cells
  • ETS2 and MESP1 play important roles in a genetic network that governs cardiopoiesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    cell migration & motility
    PHYSIOLOGICAL PROCESS development
    text
  • heart involution and morphogenesis
  • mesodermal cell migration
  • PATHWAY
    metabolism
    signaling signal transduction
    notch signaling pathway
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with MESP2 (down-regulated in the later stages of development by the activities of MESP2 in the wild-type embryo)
  • directly binds to regulatory DNA sequences located in the promoter of many key genes in the core cardiac transcriptional machinery, resulting in their rapid upregulation
  • ETS2 plays multifaceted and essential role in cardiogenesis and in combination with MESP1 reprograms human dermal fibroblasts into cardiac progenitors
  • ETS2 plays multifaceted and essential role in cardiogenesis and in combination with MESP1 reprograms human dermal fibroblasts into cardiac progenitors
  • cell & other
    REGULATION
    activated by NOTCH1 (activated NOTCH1 knock-in significantly upregulates MESP1 expression, even in the absence of a Notch signal mediator, PSEN1)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS