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FLASH GENE
Symbol FCRL3 contributors: mct/npt - updated : 18-05-2009
HGNC name Fc receptor-like 3
HGNC id 18506
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a hydrophobic signal peptide
  • six extracellular C2 type Ig-like domains
  • seven N-linked glycosylation sites
  • an uncharged transmembrane segment
  • a 140-amino acid cytoplasmic tail with 1 ITAM (immunoreceptor tyrosine-based activation motif)
  • one ITIM (immunoreceptor tyrosine-based inhibitory motif)
  • an ITAM-like region
    • HOMOLOGY
    interspecies homolog to murine Fcrl5
    Homologene
    FAMILY
  • immunoglobulin receptor superfamily
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • receptor for the fc region of complexed immunoglobulins gamma
  • playing a role in immunity and autoimmune disorders
  • playing a role in regulating activation of normal B cells and possibly the development of neoplasia
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility rheumatoid arthritis (RA) and several autoimmunities
    Variant & Polymorphism SNP
  • SNP increasing the risk of rheumatoid arthritis and several autoimmunities
  • promoter polymorphism of FCRL3 (rs7528684) is associated with an increased risk of developing RA in Dutch Caucasians
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS