Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAPK15 contributors: mct - updated : 28-03-2017
HGNC name mitogen-activated protein kinase 15
HGNC id 24667
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two SH3-binding motifs in the C-terminal region
  • HOMOLOGY
    intraspecies homolog to ERK7
    Homologene
    FAMILY
  • SER/THR protein kinase family
  • MAP kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as elk-1
  • involved in protein amino acid phosphorylation
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
  • protein
  • MAP1LC3B, GABARAP and GABARAPL1 are novel interactors of MAPK15, a MAP kinase involved in cell proliferation and transformation
  • cell & other
    REGULATION
    activated by tyrosine and threonine phosphorylation
    an Src-dependent signaling pathway
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS