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FLASH GENE
Symbol OLFM4 contributors: mct - updated : 04-07-2011
HGNC name OLFM4 olfactomedin 4
HGNC id 17190
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one signal peptide
  • six N-linked glycosylation motif
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • olfactomedin-related protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having a possible matrix-related function in differentiation
  • facilitates cell adhesion and its potential interaction with endogenous cell surface lectins and cadherin may mediate this function
  • involved in colon cancer adhesion and metastasis
  • exerts considerable influence on the host defense against H. pylori infection acting through NOD1 and NOD2 mediated NF-kappaB activation and subsequent cytokines and chemokines production
  • plays an important role in myeloid leukemia cellular functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    of OLFM-4 mRNA was observed in the endometrium of endometriosis patients (
    constitutional     --over  
    in inflammatory bowel diseases and Helicobacter pylori infected patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a useful marker for tumor differentiation and progression of human colon carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    induction of OLFM4-mediated effects may contribute to the therapeutic value of ATRA (all-trans-retinoic acid)
    ANIMAL & CELL MODELS