Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDKN2AIP contributors: mct/pgu - updated : 21-04-2009
HGNC name CDKN2A interacting protein
HGNC id 24325
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus rgd1305302
Homologene
FAMILY
CATEGORY RNA associated , transcription factor , signaling
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleolus
text colocalizing with p14ARF
basic FUNCTION
  • enhance ARF-dependent and -independent wild-type TP53 function
  • playing a role in senescence of primary cells and activating pathways for cell cycle control and tumor suppression
  • plays a dual role in regulating p53-mediated senescence and apoptosis, the two major tumor suppressor mechanisms
  • required for normal progression and completion of cell division and its absence causes mitotic catastrophe/apoptosisb
  • pleiotropic regulator with widespread effects
  • has a vital role in genome preservation and tumor suppression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    component of the p14ARF-TP53-CDKN1A (p21) pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein p14ARF
    cell & other
    REGULATION
    repressed by degradation by MDM2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    causes premature senescence of fibroblasts
    constitutional        
    causes aneuploidy and apoptosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    CDKN2AIP siRNA is an effective novel cancer therapeutic agent
    ANIMAL & CELL MODELS