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FLASH GENE
Symbol DOCK5 contributors: mct - updated : 11-01-2017
HGNC name dedicator of cytokinesis 5
HGNC id 23476
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
SH3 domain, a DHR2 domain
HOMOLOGY
interspecies homolog to murine BC016533
Homologene
FAMILY DOCK family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • potential guanine nucleotide exchange factor
  • DOCK1 and DOCK5 are critical regulators of the fusion step during primary myogenesis
  • potential role of DOCK5 in human obesity
  • DOCK1 and DOCK5 are not the important exchange factors regulating RAC1 activity during the establishment and maintenance of the glomerular barrier
  • atypical guanine nucleotide exchange factor (GEF) for RAC1, that is essential for mast cell degranulation
  • is a key signaling adaptor that orchestrates remodeling of the microtubule network essential for mast cell degranulation
  • DOCK5 acts with DOCK2 in neutrophils to regulate multiple cellular functions
  • DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation
  • expression of TNS3 and DOCK5 concomitantly increase during osteoclast differentiation
  • DOCK5 and TNS3 cooperate for osteoclast activity, to ensure the correct organization of podosomes
  • is a key regulator of epithelial invasion and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • unlike DOCK5, DOCK1 bound to phosphatidic acid (PA) through the C-terminal polybasic amino acid cluster and was localized to dorsal ruffles
  • functions as a key signaling adaptor that links FCER1A signals to microtubule dynamics during mast cell degranulation
  • suppression of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of RHO and RAC1 GTPases
  • TNS3 regulate DOCK5, a guanine nucleotide exchange factor for the GTPase RAC1, and to modulate podosome-based adhesion structures in osteoclasts
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularboneostéoporosis
    pharmacological inhibition of DOCK5 is a novel therapeutic route for fighting osteolytic diseases while preserving bone formation
    ANIMAL & CELL MODELS
  • adult Dock5(-/-) mice have increased trabecular bone mass, and also have normal hypertrophic cartilage and cartilage trabecular network
  • Dock5-deficient mice exhibit resistance to systemic and cutaneous anaphylaxis