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FLASH GENE
Symbol CCNY contributors: mct - updated : 07-02-2014
HGNC name cyclin Y
HGNC id 23354
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal cyclin domain
  • HOMOLOGY
    interspecies homolog to murine Ccny (98.2pc)
    homolog to rattus Ccny (97.9pc)
    Homologene
    FAMILY
  • cyclin family
  • cyclin Y subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • controls cell division cycles and regulates cyclin-dependent kinases (18060517)
  • might play an important role in glioma tumorigenisis
  • role of CCNY as a clinically relevant human oncoprotein
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the SETD1A complex, including CCNY, RBBP5, ASH2L, WDR5, and WDR82, associating with SETD1B (Lee 2007)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CCNY, was identified as a CDK14 interacting protein
  • binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PRKACA phosphorylation site
  • by binding to N-myristoylated CCNY, CDK16 is targeted to the plasma membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Crohn's disease (Henckaerts 2009)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS