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FLASH GENE
Symbol ZFP90 contributors: mct - updated : 09-09-2016
HGNC name zinc finger protein 90 homolog (mouse)
HGNC id 23329
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 13 C2H2-type zinc fingers
  • a KRAB domain exhibiting repressing activity, repressor domain derived from the proteins Egr-1, Oct2A and Dr1 (Thiel 2001)
  • individual domains differentially contributing to zinc-dependent target DNA binding (Lange 1995)
  • HOMOLOGY
    Homologene
    FAMILY Krueppel C2H2-type zinc finger protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may function as a repressor or silencer protein , and most likely exerts its repressing activity upon
  • zinc-dependent binding to DNA
  • may be involved in proper spermatogenesis by
  • repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid
    cell state
    CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility To colorectal cancer (CRC)
    Variant & Polymorphism SNP
  • 23 SNPs associated with CRC
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS