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FLASH GENE
Symbol KCTD10 contributors: SGE/npt - updated : 12-07-2013
HGNC name potassium channel tetramerisation domain containing 10
HGNC id 23236
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one BTB (POZ) domain
    • conjugated PhosphoP
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Kctd10 (98.4pc)
    intraspecies homolog to PDIP1
    Homologene
    FAMILY
  • polymerase delta-interacting protein 1 (PDIP1) gene family
  • KCTD10/KCTD13/TNFAIP1 family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • K+ channel activity
  • may be associated with DNA synthesis and cell proliferation (Wang 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text potassium ion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with the small subunit of DNA polymerase delta and PCNA (Wang 2009)
  • TNFAIP1 overexpression resulted in ubiquitin-mediated degradation of KCTD10 proteins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other
  • KCTD10 (V206VT->C and i5642G->C) variants may contribute to the variation in HDL-cholesterol concentrations, particularly in subjects with high carbohydrate intakes (Junyent 2009)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS