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FLASH GENE
Symbol HTR2A contributors: mct/ - updated : 11-02-2013
HGNC name 5-hydroxytryptamine (serotonin) receptor 2A
HGNC id 5293
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a seven transmembrane segments (7TM_1) receptor
  • a PDZ domain-binding motif
  • HOMOLOGY
    interspecies homolog to rattus Htr2a (91.30 pc)
    homolog to murine Htr2a (91.51 pc)
    Homologene
    FAMILY
  • G-protein coupled receptor superfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • 5-hydroxytryptamine (serotonin) receptor, subtype 2A activating the phosphatidylinositol cycle
  • rapid modulation of spine morphology by HTR2A through kalirin-7 signaling
  • participates in diverse psychiatric disorders by regulating the activity of serotonin
  • participates in human spatial cognitive abilities and spatial working memory
  • undergoes constitutive and agonist-dependent internalization
  • involved in tracheal smooth muscle contraction, bronchoconstriction and control of aldosterone production
  • GRM2 and HTR2A form a functional heteromeric complex through which hallucinogenic drugs cross-signal to the Gi-coupled receptor
  • its activation upregulates the function of the neuronal K-Cl cotransporter SLC12A5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • HTR2A/GRM2 complex integrates serotonin and glutamate signaling to regulate the sensory gating functions of the cortex, a process that is disrupted in psychosis
  • HTR2A/GRM2 complex is necessary for the neuropsychological responses induced by hallucinogens 8)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • INADL
  • CASK
  • APBA1
  • DLG1
  • DLG4
  • target of several hallucinogens, antipsychotics, anxiolytics, and antidepressants
  • interacting with CBL (C-terminal region plays a crucial role in the temporal and spatial control of HTR2A recycling)
  • heteromeric complex between the HTR2A and GRM2, integrates ligand input, modulating signaling output and behavioral changes
  • HTR2A, HTR2B, HTR2C are implicated as being critical for induction of PTHLH and RUNX2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in brain from untreated schizophrenic subjects
    constitutional     --over  
    significantly higher level of HTR2A mRNA in platelets of patients with autistic spectrum disorders
    Susceptibility
  • to schizophrenia
  • to autism, bipolar 1 disorder
  • to panic disorder
  • to alcohol dependence
  • Variant & Polymorphism SNP , other
  • SNP in autism and in bipolar 1 disorder
  • allele T-102 increasing thre risk of schizophrenia
  • A allele may contribute to racial differences in outcomes of antidepressant treatment
  • a potential role of the T102C HTR2A polymorphism in development of alcohol dependence
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    complex HTR2A/GRM2 is a promising new target for the treatment of psychosis
    ANIMAL & CELL MODELS