basic FUNCTION
| cell cycle inhibitor and HMG-box transcription repressor |
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playing a role in tissue maintenance |
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playing roles in cell cycle progression and tumor suppression |
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transcriptional repressor participates in RAS- and MAPK14-induced premature senescence |
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participating with MAPK14 together in a G1 regulatory network |
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regulated proliferation and senescence and inhibited Wnt signaling |
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may be a molecularly and clinically relevant regulator of breast cancer transitions that eventually lead to poor prognosis |
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transcriptional repressor that negatively regulate the cell cycle |
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important effector in oncogene-induced premature senescence, a tumor suppressing mechanism |
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HMG-containing repressor transiently induced during differentiation of several cell lineages |
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temporally coordinates expression of genes involved in stratification, leading to the formation of the skin barrier |