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FLASH GENE
Symbol GSTO2 contributors: mct - updated : 09-12-2014
HGNC name glutathione S-transferase omega 2
HGNC id 23064
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • thioredoxin-like domains
  • a glutathione binding site where glutathione can form a disulfide bond with a conserved active site cysteine residue positioned near the N-terminal end of helix 1
  • HOMOLOGY
    intraspecies homolog to GSTO1
    Homologene
    FAMILY GST superfamily, omega family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • having glutathione transferase activity
  • may play an important role in cellular signaling
  • two isozymes (GSTO1 and GSTO2) have significant DHA reductase (DHAR) activity
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to ovarian cancer
  • to late onset Alzheimer disease (Webster 2009)
  • Variant & Polymorphism other polymorphism associated with the risk of ovarian cancer
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS