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FLASH GENE
Symbol NLRP8 contributors: mct - updated : 01-12-2020
HGNC name NLR family, pyrin domain containing 8
HGNC id 22940
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DAPIN domain
  • a NACHT domain
  • a leucine-rich repeat (LRR) region
  • HOMOLOGY
    Homologene
    FAMILY NALP family, caterpiller family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cells response to microbial infection (Tschopp 2003)
  • play important roles in both mammalian innate immune system and reproductive system (Tian 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to lung cancer
    Variant & Polymorphism other rs402969, NLRP8, C > T, were identified as novel lung cancer susceptibility variants
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS