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FLASH GENE
Symbol ZNHIT1 contributors: mct - updated : 18-06-2019
HGNC name zinc finger, HIT type 1
HGNC id 21688
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a poly-lys domain
  • one HIT-type zinc finger
  • HOMOLOGY
    interspecies homolog to murine Znhit1
    homolog to rattus LOC360784
    Homologene
    FAMILY
  • ZNHIT1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • plays an important role in stress-induced cell-fate decisions (Cuadrado 2007)
  • ZNHIT1 maintains the interaction between H2AFZ and VPS72 through enhancing VPS72 phosphorylation
  • dominant role of ZNHIT1/H2AFZ in controlling mammalian organ development and tissue homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZNHIT1 has been shown to regulate histone variant H2AFZ deposition, thereby controlling gene transcription
  • ZNHIT1 enhances the interaction between H2AFZ and VPS72
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS