basic FUNCTION
| t-RNA intron endonuclease activity |
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regulation of transcription |
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novel regulator of islet cell development (Soyer 2010) |
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critical for development and associated with an expanding list of serious disease conditions including major histocompatibility (MHC) class II deficiency and ciliaophathies (Aftab 2008) |
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directs islet cell differentiation downstream of NEUROG3 (Smith 2010) |
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acts downstream of the pro-endocrine factor NEUROG3 (Smith 2010) |
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new factor in endoderm and islet development, that is required for the differentiation of four of the five islet cell types and for the production of insulin (Smith 2010) |