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FLASH GENE
Symbol KCTD5 contributors: mct - updated : 02-03-2014
HGNC name potassium channel tetramerisation domain containing 5
HGNC id 21423
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a K+ channel tetramerisation domain
  • a bric-a-brac, tramtrak and broad complex (BTB) domain that is most similar to the tetramerization domain (T1) of voltage-gated potassium channels
  • same BTB (bric-a-brac, tramtrack, broad complex) domain surface mediates the assembly of five KCTD5 and four voltage-gated K(+) (Kv) channel subunits
  • mono polymer heteromer , tetramer , complex
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • voltage-gated K+ channel activity
  • substrate-specific adaptor for cullin3-based E3 ligases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to form a K+ channel complex
  • interacted specifically with CUL3, and formed oligomers through its BTB domain (interaction with cullin3 showed that, in addition to the BTB domain, some AAs in the N-terminus of KCTD5 are required for binding to cullin3)
  • KCTD5 or Cullin3 overexpression increased ZNF711 protein stability
  • cell & other
    REGULATION
    activated by upregulated post-transcriptionally in peripheral blood lymphocytes stimulated through the T-cell receptor
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS