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FLASH GENE
Symbol HMGCLL1 contributors: mct - updated : 22-03-2017
HGNC name 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
HGNC id 21359
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal myristoylation motif
  • a HMGL-like region
  • lacks the peroxisomal targeting sequence C(K/R)L present in HMGCL
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • dual location in the endoplasmic reticulum (ER) and cytosol, but not in mitochondria or peroxisomes
  • basic FUNCTION
  • may have a catalytic activity
  • having metabolic function, mostly at the pulmonary and brain level
  • extramitochondrial hydroxymethylglutaryl-CoA lyase
  • may be an active, extramitochondrial HMG-CoA lyase and may be subject to post-translational myristoylation
  • plausible physiological roles for HMGCLL1 in either lipid biosynthesis and/or energy metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS