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FLASH GENE
Symbol RHEBL1 contributors: mct - updated : 19-12-2015
HGNC name Ras homolog enriched in brain like 1
HGNC id 21166
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Rhebl1
homolog to rattus Rhebl1
intraspecies paralog to RHEB
Homologene
FAMILY HEB family
CATEGORY signaling
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
text
  • RHEB and RHEBL1 localize primarily to the endoplasmic reticulum and Golgi apparatus
  • basic FUNCTION
  • mediating signal transduction
  • positive regulator of NF-kappa B-mediated gene transcription
  • cytoplasm protein but not evenly distributed in cytoplasm
  • when overexpressed in the cells
  • possible role of RHEB and RHEBL1 in regulating de novo pyrimidine nucleotide synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • may be impacting the MTOR pathway in a different manner than RHEB
  • RHEB and RHEBL1 are unique members of the Ras superfamily and play central roles in regulating protein synthesis and cell growth by activating MTOR
  • RHEB proteins binds to CAD protein (RHEB and RHEBL1 binds CAD in a GTP- and effector domain-dependent manner)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    DHH-RHEBL1 fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2-positive childhood AML
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS