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FLASH GENE
Symbol TRIM68 contributors: npt - updated : 06-02-2009
HGNC name tripartite motif-containing 68
HGNC id 21161
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING-type zinc finger
  • a B-box type zinc finger
  • a coiled-coil domain
  • a B30.2/SPRY domain
  • HOMOLOGY
    interspecies homolog to murine Trim68 (77.9 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a role of autoantigen in systemic lupus erythematosus and primary Sjoegren syndrome (Billaut-Mulot 2001, Ozato 2008)
  • being a putative E3 ubiquitin ligase (Miyajima 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with androgen receptor (Miyajima 2008)
  • cell & other
    REGULATION
    induced by IFN-gamma and LPS
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • being a potentially therapeutic target for prostate cancer (Miyajima 2008)
  • ANIMAL & CELL MODELS