basic FUNCTION
| having E3 ubiquitin ligase activity |
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may function as a positive regulator in the T-cell receptor signaling pathway |
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acts as a ubiquitin E3-ligase regulating the cellular levels of RARRES3 through proteasomal degradation |
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involved in the down-regulation of HIV-1 replication not only in cell lines, but also in peripheral blood mononuclear cells |
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could function to recruit host factor(s) controlling HIV-1 transcription to the ubiquitin-proteasome pathway |
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functions as a negative regulator of RARRES3 signaling |
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down-modulating HIV replication and inhibiting pathogen-induced cytokine production |
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regulate the IFIH1/DDX58 innate antiviral response |
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catalysed the conversion of all input protein to higher molecular weight ubiquitinated forms |
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RNF125 plays a new role in innate immune response by regulating TRIM14 ubiquitination and degradation |