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FLASH GENE
Symbol RNF125 contributors: mct/pgu - updated : 09-07-2014
HGNC name ring finger protein 125
HGNC id 21150
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal C3HC4 (Cys(3)-His-Cys(4)) RING finger domain, important for E3 ubiquitin protein ligase
  • a C2HC (Cys(2)-His-Cys)- and two C2H2 (Cys(2)-His(2))-type zinc fingers
  • a UIM (ubiquitin-interacting motif), binding Lys(48)-linked polyubiquitin chains and together with the RING domain, required for auto-ubiquitination
  • crucial role for the C-terminus in its function
  • HOMOLOGY
    interspecies homolog to murine 4930553F04Rik
    homolog to rattus LOC361296
    intraspecies paralog to RNF114
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text associates with membranes and is excluded from the nucleus through myristoylation
    basic FUNCTION
  • having E3 ubiquitin ligase activity
  • may function as a positive regulator in the T-cell receptor signaling pathway
  • acts as a ubiquitin E3-ligase regulating the cellular levels of RARRES3 through proteasomal degradation
  • involved in the down-regulation of HIV-1 replication not only in cell lines, but also in peripheral blood mononuclear cells
  • could function to recruit host factor(s) controlling HIV-1 transcription to the ubiquitin-proteasome pathway
  • functions as a negative regulator of RARRES3 signaling
  • down-modulating HIV replication and inhibiting pathogen-induced cytokine production
  • regulate the IFIH1/DDX58 innate antiviral response
  • catalysed the conversion of all input protein to higher molecular weight ubiquitinated forms
  • RNF125 plays a new role in innate immune response by regulating TRIM14 ubiquitination and degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
  • may play an important role in the regulation of IRF3 activity
  • interacting with UBE2E2 and ISG15
  • RNF125 is a negative regulator of TRIM14 in the innate antiviral immune response
  • cell & other
    REGULATION
    Other UBE2E2 and ISG15 are functional regulators of RNF125 E3 ligase activity, which regulates the level of ubiquitin and ISG15 conjugation of DDX58
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    inhibits TRIM14-mediated antiviral response
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS