basic FUNCTION
| acting as a coactivator of endogenous ER alpha target genes by binding to the promoter region after its recruitment by estrogen-bound ER alpha |
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enhancing the transcriptional activities of several nuclear receptors |
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involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA |
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like its homologue, OXR1, NCOA7 is capable of reducing the DNA damaging effects of reactive oxygen species when expressed in bacteria, indicating the protein has an activity that can contribute to oxidation resistance |
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plays an important role in the regulation of ATRA-mediated neuronal differentiation, and is a novel member of prognostic indicators for neuroblastoma |
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OXR1 and its close homolog NCOA7 are produced in many different forms either as a result of alternative splicing, or alternative transcription start sites |