Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZMYND15 contributors: mct - updated : 24-08-2022
HGNC name zinc finger, MYND domain containing 15
HGNC id 20997
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one MYND-type zinc finger
  • a pro-rich domain
  • a glu-rich domain
  • HOMOLOGY
    interspecies homolog to rattus LOC287457
    ortholog to murine Zmynd15 (85 p100)
    Homologene
    FAMILY MYND domain-containing zinc finger proteins family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • acts as a histone deacetylase-dependent transcriptional repressor and controls normal temporal expression of haploid cell genes during spermiogenesis
  • first transcriptional repressor identified to be essential for sperm production and male fertility
  • acts as a transcription repressor through the recruitment of histone deacetylase enzymes (HDACs)
  • acting as a transcription repressor to regulate spatiotemporal expression of a large subset of haploid genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with histone deacetylases and acts as a testis-specific transcriptional repressor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF14
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    results in early activation of transcription of numerous important haploid genes, depletion of late spermatids and male infertility
    constitutional germinal mutation      
    homozygous truncating mutations p.K507Sfs*3 in ZMYND15 in azoospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS