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FLASH GENE
Symbol ZFYVE19 contributors: mct - updated : 23-09-2014
HGNC name zinc finger, FYVE domain containing 19
HGNC id 20758
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a FYVE-type zinc finger domain
HOMOLOGY
interspecies ortholog to murine Zfyve19
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
basic FUNCTION
  • ubiquitin protein ligase activity
  • involved in regulation of transcription, DNA-dependent
  • key regulator of the abscission checkpoint, functioning through the most downstream component of the ESCRT machinery, the ATPase VPS4A
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
  • abscission checkpoint is mediated by ZFYVE19 and CHMP4C through retention of VPS4A at the midbody ring
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with MLL gene in a patient with AML-M2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS