| M6a knockdown with small interference RNA methodology showed that M6a low-expressing neurons display decreased filopodia number and a lower density of synaptophysin clusters | |
decrease in both the number of neuronal markers and the number of differentiating neuronal cells (cholinergic, catecholaminergic, and GABAergic neurons) from neural stem cells in knockdown mouse ES cell lines (D3m-shM6A) |
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suppression of GPM6A expression using shRNA in human ES cells led to a decrease in both the expression of neuroectodermal-associated genes and the number of NSCs derived from B2h-shM6A cells |
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increase of the expression of neuroectodermal-associated genes and the number of differentiated neuronal cells (cholinergic, catecholaminergic, and GABAergic neurons) from Human neural stem cells derived from B2h-oeM6A cells which overexpress GPM6A |
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Src-deficient SYF cells over-expressing M6a fail to promote filopodia formation |
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reduced M6 levels in Drosophilia triggered a mild rough-eye phenotype, and a defective response to light |
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Gpm6a-deficient mice develop normally and lack obvious behavioral abnormalities but when mildly stressed by single-housing, tthey develop a striking claustrophobia-like phenotype |