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FLASH GENE
Symbol TPH2 contributors: mct - updated : 08-02-2008
HGNC name tryptophan hydroxylase 2
HGNC id 20692
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal regulatory domain being the source of TPH2 instability and reduced solubility
  • an amino acid-binding ACT motif
  • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine Tph2
    homolog to rattus Tph2
    Homologene
    FAMILY biopterin-dependent aromatic amino acid hydroxylase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • rate-limiting enzyme in serotonin biosynthesis
  • having several functions in peripheral tissues, including the maintenance of vascular tone and gut motility
  • controling brain serotonin synthesis
  • involved in melatonin biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    ferrous ion
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to autism (minor role )
  • to attention-deficit/hyperactivity disorder
  • to bipolar affective disorder
  • Variant & Polymorphism other Pro206Ser appears to be an infrequent susceptibility variant with a relatively high penetrance in bipolar affective disorder
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS