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FLASH GENE
Symbol TXNRD3 contributors: mct - updated : 19-10-2022
HGNC name thioredoxin reductase 3
HGNC id 20667
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a FAD-binding domain
  • a NADPH-binding domain
  • conjugated Other
    HOMOLOGY
    interspecies homolog to rattus LOC297437
    ortholog to murine Txnrd3
    Homologene
    FAMILY
  • pyridine nucleotide-disulfide oxidoreductase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acting on NADH or NADPH as acceptor
  • may have an essential role in redox-regulated cell signaling
  • mitochondrial TXNRD3 is much less dependent upon the use of selenocysteine (Sec) for the reduction of small molecules, as TXNRD1
  • plays a critical role in male reproduction via the thiol redox control of spermatogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • FAD
  • NADPH
  • protein
  • GPX2, TXNRD2 and TXNRD3 are regulated by WNT signalling in the intestinal epithelium
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Txnrd3 deficiency leads to fertility impairment in male mice