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FLASH GENE

Symbol

MBD5

contributors: /mct - updated : 24-11-2021

HGNC name	methyl-CpG binding domain protein 5
HGNC id	20444

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	CpG binding domain
	a PWWP domain
	a putative Methyl-Binding Domain (MBD)

HOMOLOGY

interspecies

homolog to rattus LOC311026

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome,heterochromosome
text	colocalize with heterochromatin (Laget 2010)

basic FUNCTION	may be a transcription coactivator
	may contribute to the formation or function of heterochromatin (Laget 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

interacts with KIAA1549

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL2Q23 , MRD1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       ID via EHMT1-associated chromatin modification module

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS