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FLASH GENE
Symbol MBD5 contributors: /mct - updated : 24-11-2021
HGNC name methyl-CpG binding domain protein 5
HGNC id 20444
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • CpG binding domain
  • a PWWP domain
  • a putative Methyl-Binding Domain (MBD)
  • HOMOLOGY
    interspecies homolog to rattus LOC311026
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    text colocalize with heterochromatin (Laget 2010)
    basic FUNCTION
  • may be a transcription coactivator
  • may contribute to the formation or function of heterochromatin (Laget 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacts with KIAA1549
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q23 , MRD1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    ID via EHMT1-associated chromatin modification module
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS