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FLASH GENE
Symbol USP46 contributors: mct/npt - updated : 08-10-2017
HGNC name ubiquitin specific protease 46
HGNC id 20075
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a UCH domain
  • HOMOLOGY
    interspecies homolog to murine Usp46
    homolog to rattus LOC289584
    intraspecies paralog to USP12
    Homologene
    FAMILY
  • peptidase family C19
  • USP12/USP46 subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in ubiquitin-dependent protein catabolism
  • tumor suppressor role of USP46 in promoting PHLPP1 expression and inhibiting AKT1 signaling in colon cancer
  • role of the DUB (deubiquitinating enzyme) USP46 in the nervous system
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with WDR20 (WDR20, a WD40-repeat containing protein, is a common binding partner of WDR48, USP12, and USP46) (Kee 2010)
  • binds to PHLPP1 and directly removes the polyubiquitin chains from PHLPP1 in cells
  • WDR48 interacts with the USP46 fingers subdomain via a relatively small, highly polar surface on the top center of the WDR48 beta propeller
  • WDR48 is a WD40 repeat protein, which binds and activates three important deubiquitinating enzymes (DUBs), USP1, USP12 and USP46
  • cell & other
    REGULATION
    Other is regulated by two WD40-repeat (WDR) proteins, WDR48/UAF1 and WDR20
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS