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FLASH GENE
Symbol USP39 contributors: mct - updated : 03-05-2011
HGNC name ubiquitin specific protease 39
HGNC id 20071
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a UCH domain
  • an ubiquitin-protease domain
  • HOMOLOGY
    interspecies homolog to murine Usp39
    homolog to rattus LOC297336
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • pre mRNA splicing factor activity
  • also involved in ubiquitin dependent protein catabolism
  • required to maintain the spindle checkpoint and support successful cytokinesis
  • involved in splicing of Aurora B and other mRNAs that are essential for proper spindle checkpoint function
  • CELLULAR PROCESS nucleotide, RNA splicing
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of RNA splicing machinery
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • zebrafish usp39 mutants exhibit microcephaly and adenohypophyseal cell lineage expansion without apparent changes in major hypothalamic hormonal and regulatory signals