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FLASH GENE
Symbol USP36 contributors: mct/npt - updated : 28-04-2020
HGNC name ubiquitin specific protease 36
HGNC id 20062
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a UCH domain
  • a PEST motif
  • HOMOLOGY
    Homologene
    FAMILY
  • peptidase family c19
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    text localized to nucleoli via the C-terminal region, which contains basic amino acid stretches (Endo 2009)
    basic FUNCTION
  • having growth-suppressing activity
  • have a deubiquitinating (DUB) enzyme activity (Kim 2005)
  • inducing arrest in G1 phase upon controlled expression
  • deubiquitylating enzyme, that regulates nucleolar activity in mammalian cells (Endo 2009)
  • plays a crucial role in regulating the structure and function of nucleoli (Endo 2009)
  • controls selective autophagy activation
  • is a novel H2B deubiquitinase which shed light on its additional functions in regulating gene expression
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • by deubiquitylating various nucleolar substrate proteins including NPM1 and FBL, USP36 plays a crucial role in regulating the structure and function of nucleoli
  • FBL is a USP36 substrate protein in nucleoli
  • regulates the protein stability of SOD2
  • USP36 function in SQSTM1-dependent selective autophagy
  • nucleolar USP36 is a novel MYC deubiquitinase that controls the end-point of MYC degradation pathway in the nucleolus
  • USP36 binds to and regulates the actions of NEDD4L over different substrates affecting their expression and functions
  • USP36 regulates PPME1 as a DUB and participates in the ERK and Akt signaling pathways.
  • important role of MELK and USP36 in mediating EZH2 stability in natural killer/T-cell lymphoma (NKTL)
  • USP36 is regulator for the PRKN-dependent mitophagy at least in part via the BECN1-ATG14 pathway
  • cell & other
    REGULATION
    induced by interleukin-3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer compared to normal ovary and its transcripts were identified in ascites and serum of ovarian cancer patients (Li 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS