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FLASH GENE
Symbol ABCC5 contributors: - updated : 20-09-2006
HGNC name ATP-binding cassette, sub-family C (CFTR/MRP), member 5
HGNC id 56
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ATP binding, each containing highly conserved Walker motifs
  • two transmembrane (2TM) domains (2 x 6 segments)
  • HOMOLOGY
    interspecies homolog to C.elegans F14F4.3B
    Homologene
    FAMILY
  • ATP binding cassette superfamily, subfamily C (CFTR/MRP)
  • CATEGORY signaling , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putative glutathione (GSH) conjugate (GS-x) pump or canalicutar multispecific anion transporter, involved in drug resistance (thiopurine to potecan, doxorubicin)
  • acting as a multispecific organic anion pump which can transport nucleotide analogs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS