basic FUNCTION
| catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate |
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mediating a wide variety of cellular stimuli |
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shuttles between the nucleus and the cytoplasm, and nuclear import1 is mediated by its Ca2+-dependent interaction with importin beta1 |
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plays an important suppressive role in the development and progression of ESCC (esophageal squamous cell carcinoma) |
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mediates regulatory signaling of energy metabolism, calcium homeostasis and intracellular movements |
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acts as a functional tumor suppressor involved in gastric carcinogenesis |