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FLASH GENE
Symbol PLCD1 contributors: mct - updated : 01-02-2010
HGNC name phospholipase C, delta 1
HGNC id 9060
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CaM-like region in its N-terminus, capable of binding directly to RAlA
  • a pleckstrin homology (PH)
  • two helical EF-hand domain
  • a catalytic domains
  • a C2 domain
  • a PI-PLC x-box domain
  • a PI-PLC y-box domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • accumulates in the nucleus when its nuclear export signal sequence is disrupted
  • an increase in the levels of intracellular Ca2+ shifts the equilibrium to the nuclear import of PLCD1
  • basic FUNCTION
  • catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate
  • mediating a wide variety of cellular stimuli
  • shuttles between the nucleus and the cytoplasm, and nuclear import1 is mediated by its Ca2+-dependent interaction with importin beta1
  • plays an important suppressive role in the development and progression of ESCC (esophageal squamous cell carcinoma)
  • mediates regulatory signaling of energy metabolism, calcium homeostasis and intracellular movements
  • acts as a functional tumor suppressor involved in gastric carcinogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds three calcium ions per subunit, two of the calcium ions are bound to the C2 domain
  • protein
  • activity of PLCD1 is controlled by the amount of bound PLCB2 that changes with displacement of the enzyme by heterotrimeric or small G proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LKN
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    in esophageal squamous cell carcinoma (ESCC)
    tumoral     --other  
    ectopic expression in silenced gastric tumor cells dramatically inhibited their clonogenicity and migration
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS