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FLASH GENE
Symbol DOK4 contributors: - updated : 16-04-2005
HGNC name docking protein 4
HGNC id 19868
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • pleckstrin homology and PTB
  • short carboxl-terminal tail containing a few tyrosine motifs
    • HOMOLOGY
    interspecies ortholog to murine Dok4
    intraspecies homolog to DOK5
    Homologene
    FAMILY DOK family
    CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be involved in the regulation of the immune response induced by T cells
  • signaling proteins with potential roles in insulin and IGF-1 action
  • activates MAPK
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • insulin recptor binding
  • binding SH2 proteins like CRK, SRC, FYN
    • cell & other
    REGULATION
    Other tyrosine-phosphorylated in response to insulin and IGF-1
    dephosphorylated by a pervanate-inhibitable phosphatase
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS