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FLASH GENE
Symbol FNBP4 contributors: mct/npt - updated : 15-01-2010
HGNC name formin binding protein 4
HGNC id 19752
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two WW domains
  • Pro-Arg motif often overlaping with SH3 domain motifs within protein sequences (Bedford 2000)
  • HOMOLOGY
    interspecies homolog to murine Fnbp4
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • ca compete with AblSH3 domain
  • can perform function similar to SH3 domains
  • might regulate SH3 interactions with target proteins
  • TP53-regulated molecule whose WW domains bind to Pro-Arg-rich cellular proteins (Bedford 2000)
  • its expression is indirectly regulated by TP53, through downregulation of a labile inhibitor of FNBP4 expression (Depraetere 1999)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds with high affinity to proline-rich sequences similar to SH3 ligands
  • interact with formin
  • interacting with KHDRBS1, through its WW domain (Bedford 2000)
  • cell & other
    REGULATION
    Other up-regulated by p53 in thymocytes undergoing programmed cell death
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS