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FLASH GENE
Symbol PACRG contributors: mct - updated : 11-05-2022
HGNC name parkin coregulated
HGNC id 19152
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure
  • PACRG adopts a helical repeat fold with a loop that interacts with MEIG1
  • HOMOLOGY
    interspecies homolog to murine Pacrg (91.7 pc)
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    text coexpressed with PARK2
    basic FUNCTION
  • suppressing cell-death induced by accumulation of unfolded GPR37 (PAELR)
  • facilitating the formation of GPR37 inclusions
  • unrecognized sensory/signaling functions for PACRG with a role for this protein in promoting longevity
  • plays a role in regulating specific ciliary dyneins during microtubule sliding
  • may play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson's disease
  • plays a role in regulating dynein-driven microtubule sliding in motile cilia
  • PACRG and VPS25 form the inner junction between the A- and B-tubule along the length of all nine ciliary doublet microtubules
  • function of the PACRG family of proteins and MEIG1 in regulating axoneme assembly
  • PACRG may play important roles in regulation of gene transcription
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with HSP70, HSP90, chaperonin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with STIP1, PARK2, GPR37, HSPA8, CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8
  • binding to microtubules and alpha/beta-tubulin heterodimers with high affinity
  • MEIG1/PACRG forms a complex in the manchette and this complex is necessary to transport cargos, such as SPAG16, to build the sperm flagella
  • EFHC1 (EF-hand containing 1), a potential PACRG interaction partner similarly associated with the protofilament ribbon and ciliary motility, also positively regulates lifespan
  • PACRG and FAP20 comprise the inner junction bridge that serves as a hub for both directly modulating dynein-driven microtubule sliding, as well as for the assembly of additional ciliary components that play essential roles in generating coordinated ciliary beating
  • PACRG binds to the adaptor protein meiosis expressed gene 1 (MEIG1)
  • similarly to PRKN, PACRG promoted NFKB1 activation in response to TNF
  • cell & other
  • PACRG interacts with the radial spokes
  • binds at the inner junction between doublet microtubules of the axoneme, a structure found in flagella and cilia
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PARK2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    Parkinson disease (component of Lewy bodies )
    tumoral     --low  
    in clear-cell renal cell carcinomas (ccRCCs) compared with nonmalignant tissues
    Susceptibility
  • to leprosy
  • to azoospermia
  • Variant & Polymorphism SNP , other
  • increasing the susceptibility to leprosy
  • variation in the promoter was demonstrated to be a risk factor associated with azoospermia
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    small molecules that block MEIG1/PACRG interaction are likely ideal targets for the development of male contraconception drugs
    ANIMAL & CELL MODELS