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FLASH GENE
Symbol NALCN contributors: mct/pgu - updated : 22-11-2013
HGNC name sodium leak channel, non-selective
HGNC id 19082
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Vgcnl1 (98.6 pc)
homolog to murine Vgcnl1 (97.4 pc)
Homologene
FAMILY
  • 24-transmembrane domain (24-TM) ion channel superfamily
  • CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • mediating the entry of calcium ions into excitable cells
  • also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death
  • nonselective cation channel, forming the background Na(+) leak conductance and controling neuronal excitability
  • has been shown to be responsible for the TTX-resistant sodium leak current implicated in the regulation of neuronal excitability
  • extracellular Ca(2+) influences neuronal excitability through the UNC79-UNC80-NALCN complex in a G protein-dependent fashion
  • is essential for the depolarization of clock neurons in the morning and the maintenance of normal circadian rhythms
  • role in conducting the background Na(+) current that depolarizes resting membrane properties of pacemaker neurons
  • can serves as a variable sensor that responds to calcium or sodium ion flux, depending on whether the total cellular current density is generated more from calcium-selective or sodium-selective channels
  • forms a voltage-independent ion channel with a role in the regulation of neuronal excitability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text ionic channel
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UNC80 is a protein that is associated with the NALCN and is required for the activation of this channel by the neuropeptide substance P through GPCRs in a G-protein-independent fashion
  • UNC80 is a large protein that is necessary for the stability and function of NALCN and for bridging NALCN to UNC79 to form a functional complex
  • cell & other
    REGULATION
    activated by M3 muscarinic receptors in a pancreatic beta-cell line
    Other permeant to sodium ions, dependent on Src activation and resistant to TTX
    ASSOCIATED DISORDERS
    corresponding disease(s) IHPRF , CLIFAHDD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Nalcn mutant mice have a severely disrupted respiratory rhythm and die within 24 hours of birth