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FLASH GENE
Symbol ODF4 contributors: mct - updated : 04-06-2020
HGNC name outer dense fiber of sperm tails 4
HGNC id 19056
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • may have a role in spermatids
  • may play important roles in human spermatogenesis
  • is a testis-specific gene whose overexpression has been detected in chronic myeloid leukemia patients
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • MAGEA3, MAGEB4, and ODF4 may be particularly useful for diagnostic and surveillance of bladder transitional cell carcinoma (TCC) in the form of a multi-biomarker panel
  • ODF4 and RHOXF2 are proposed as putative breast cancer biomarkers at the transcript level
  • Therapy target
    ANIMAL & CELL MODELS