protein
| VRK3 enhances the phosphatase activity of DUSP3 by a mechanism independent of its kinase activity, and direct interaction of DUSP3 with VRK3 posttranslationally regulates ERK signalling |
|
evidence for the role of bivalent cations in structural stabilities of VRK1, VRK2, VRK3 |
|
phosphorylates the nuclear envelope protein barrier-to-autointegration factor (BANF1) on Ser4 |
|
VRK3-mediated phosphorylation of BANF1 may facilitate DNA replication or gene expression by facilitating the dissociation of nuclear envelope proteins and chromatin during interphase |
|
VRK3 is a negative regulator of ERK (MAPK3 and MAPK1) that protects cells from persistent ERK activation and inhibits ERK-dependent apoptosis |
|
under oxidative stress, VRK3 migrates from the nucleus to the cytoplasm, which increases its chance of interacting with RNF144A, thereby promoting the degradation of VRK3 |