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FLASH GENE
Symbol VRK3 contributors: mct - updated : 28-09-2017
HGNC name vaccinia related kinase 3
HGNC id 18996
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a protein kinase domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Vrk3 (75.5 pc)
    homolog to murine Vrk3 (75.3 pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • CK1 Ser/Thr protein kinase family
  • VRK subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • VRK3 expression levels increase during interphase
  • basic FUNCTION
  • may be involved in protein amino acid phosphorylation
  • VRK3 still shares striking structural similarity with VRK2, and appears to be locked in a pseudoactive conformation
  • pseudokinase that is catalytically inactive due to changes in motifs that are essential for kinase activity
  • acts as an active kinase as well as a signaling scaffold in cells
  • kinase activity of VRK3 is involved in the regulation of the cell cycle
  • VRK3 protects cells by suppressing oxidative stress-induced ERK, and RNF144A sensitively regulates this process
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • VRK3 enhances the phosphatase activity of DUSP3 by a mechanism independent of its kinase activity, and direct interaction of DUSP3 with VRK3 posttranslationally regulates ERK signalling
  • evidence for the role of bivalent cations in structural stabilities of VRK1, VRK2, VRK3
  • phosphorylates the nuclear envelope protein barrier-to-autointegration factor (BANF1) on Ser4
  • VRK3-mediated phosphorylation of BANF1 may facilitate DNA replication or gene expression by facilitating the dissociation of nuclear envelope proteins and chromatin during interphase
  • VRK3 is a negative regulator of ERK (MAPK3 and MAPK1) that protects cells from persistent ERK activation and inhibits ERK-dependent apoptosis
  • under oxidative stress, VRK3 migrates from the nucleus to the cytoplasm, which increases its chance of interacting with RNF144A, thereby promoting the degradation of VRK3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    is a potential therapeutic target in neurodegenerative diseases.
    ANIMAL & CELL MODELS