basic FUNCTION
| DNA glycosylase/AP lyase activity, involved in repair of lesions in DNA generated during transcription and/or replication, mainly by removing oxidative products of cytosine |
|
may have a novel regulatory role in NEIL2-mediated repair under oxidative stress (Das 2007) |
|
recognizes an apurinic/apyrimidinic site exclusively |
|
able to excise base lesions from single-stranded DNA regions suggesting their preferential involvement in repair during replication and/or transcription (Dou 2008) |
|
excises oxidized DNA lesions from bubble or single-stranded structures, suggesting its involvement in transcription-coupled DNA repair (Kinslow 2008) |
|
critical role of NEIL2 and PNKP in maintenance of the mammalian mitochondrial genome |
|
oxidized base-specific DNA glycosylase, that is unique in preferentially repairing oxidative damage in transcribed genes |
|
NEIL1-mediated prereplicative repair of oxidized bases in the replicating strand, with NEIL2 providing a backup function |
|
biological role for ERCC6 and NEIL2 in transcription associated base excision repair |