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FLASH GENE
Symbol GRSF1 contributors: mct - updated : 10-07-2015
HGNC name G-rich RNA sequence binding factor 1
HGNC id 4610
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three RNA recognition motif
  • two polyadenylation signal
  • RNA binding domain designated RNA recognition motif (RRM)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    text
  • located in the nucleus as well as in the cytoplasm (PMID;
  • targeted to mitochondria where it forms granules that colocalize with foci of newly synthesized mtRNA next to mitochondrial nucleoids (PMID;
  • previously reported to localize in the cytosol, but an isoform of GRSF1 accumulates in discrete foci in the mitochondrial matrix (PMID;
  • basic FUNCTION
  • playing a role in the binding of RNAS containing the 14 bases G-rich element
  • mRNA-binding protein involved in translation activation
  • functions by selectively recruiting cellular and viral mRNAs containing 5prime UTR GRSF1 binding sites to polyribosomes, which is mediated through interactions with cellular proteins
  • implicated in the influenza viral life cycle, embryonic brain development and the regulation of apoptosis
  • functional component of several cellular signalling pathways as well as of the regulation of the cellular redox homeostasis
  • is a key regulator of posttranscriptional mitochondrial gene expression
  • regulates RNA processing in mitochondrial RNA granules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to G-rich RNA
    small molecule
    protein
  • GRSF1 up-regulates translation of GPX4 mRNA and implicate the two proteins in embryonic brain development
  • preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the MT-ND6 mRNA, and the long noncoding RNAs for MT-CYB and MT-ND5
  • interact with RNase P and required for processing of both classical and tRNA-less RNA precursors
  • GRSF1 controls translation of the SNARE protein USE1, possibly by positioning the 40S ribosomal subunit and associated translation factors in front of the translation start site
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS