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FLASH GENE
Symbol KLHL10 contributors: mct - updated : 24-08-2022
HGNC name kelch-like 10 (Drosophila)
HGNC id 18829
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one BTP/POZ domain and six Kelch repeats
HOMOLOGY
interspecies homolog to murine Klhl10
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • may be involved in regulatory/signal transduction mechanisms
  • plays an important role in male fertility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein binding
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF11
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deletion or mutation of the Klhl10 gene in Drosophila or mice results in defects in spermatogenesis or sperm maturation