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FLASH GENE
Symbol RIOK1 contributors: mct/shn - updated : 23-12-2016
HGNC name RIO kinase 1 (yeast)
HGNC id 18656
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • the region AA 1–242 comprises the so called Rio domain of RIOK1
  • HOMOLOGY
    interspecies ortholog to murine Riok1
    ortholog to rattus Riok1_predicted
    Homologene
    FAMILY
  • RIO-type serine/threonine-protein kinase family
  • protein kinase superfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • predominantly cytoplasmic
  • basic FUNCTION
  • kinase activity
  • may be involved in cell cycle control
  • specifically promotes the symmetrical methylation of nucleolin by recruiting it to the PRMT5 complex
  • kinase activity of hRio1 is essential for the recycling of the endonuclease hNob1 and its binding partner hDim2 from cytoplasmic pre-40S
  • a role in the final stages of cytoplasmic pre-40S maturation
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ubiquitous component of the PRMT5 complex, the only component of the PRMT5 complex that localizes exclusively to the cytoplasm
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • PRMT5 through N-terminal part (aa 1–291)
  • RIOK1 and CLNS1A might bind to the same site in PRMT5 and thus compete for binding
  • nucleolin
  • precursors of 40S ribosomal subunits
  • EIF1AD and LRRC47 bind to late pre-40S particles near RIOK1 and the central rRNA helix 44
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • depletion of hRio1 by RNA interference affects the last step of 18S rRNA maturation and causes defects in the recycling of several trans-acting factors from pre-40S subunits in the cytoplasm