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FLASH GENE
Symbol SPATA5 contributors: mct - updated : 12-10-2015
HGNC name spermatogenesis associated 5
HGNC id 18119
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • highly conserved ATPase domain, which is involved in a variety of cellular processes, including protein unfolding and degradation, microtubule motor movement, DNA replication, and membrane fusion
  • a putative mitochondrial targeting sequence and two AAA domains
    • HOMOLOGY
    interspecies homolog to murine Spata5
    homolog to rattus LOC361935
    Homologene
    FAMILY AAA ATPase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • involved in spermatogenesis
  • might be involved in regulating the structural integrity of mitochondria during spermatogenesis
  • might play a role in post-translational modification during cell differentiation in neuronal development
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • TWIST1-binding sequences associated with CHST11, LITAF, ROR2, and SPATA5 also bound the potential TWIST1 cofactor RREB1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EHLMRS
    Susceptibility to Alopecia areata (AA)
    Variant & Polymorphism SNP
  • SNP in an intronic region of the SPATA5 associated to susceptibility for AA
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS