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FLASH GENE
Symbol CD207 contributors: npt/shn - updated : 18-02-2012
HGNC name CD207 molecule, langerin
HGNC id 17935
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an hydrophobic signal anchor
  • a calcium dependant lectin domain
  • a glu-pro-asn motif featuring a single carbohydrate recognition domain (CRD)
  • a proline rich potential signal transduction motif (WPREPPP) and two potential N-glycosylation sites
  • HOMOLOGY
    interspecies ortholog to Cd207, Mus musculus
    ortholog to CD207, Pan troglodytes
    ortholog to Cd207, Rattus norvegicus
    Homologene
    FAMILY Ca2+ dependant (C-type) lectin family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle
    text localized in the Birbeck granules
    basic FUNCTION
  • receptor with a mannose binding specificity, leading to internalization of antigen
  • induces the formation of Birbeck granules
  • could function as an attachment factor for the HIV proteins
  • natural barrier to HIV-1 infection (
  • type II lectin with mannose specificity expressed by Langerhans cells, in epidermis and epithelia
  • cargo molecule that traffics through RAB11A-positive membrane domains of the endosomal recycling pathway (pMID: 22420646)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MYO5B/RAB11A/RAB11FIP2 platform is spatially involved in the regulation of CD207 trafficking at two distinct sites within live cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other down-regulated during Langerhans cells maturation
    up-regulated by TGF-beta
    ASSOCIATED DISORDERS
    corresponding disease(s) BBGRD
    Susceptibility to infection
    Variant & Polymorphism other certain haplotypes may differ in their binding to pathogens and thus might be associated with susceptibility to infection
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS