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FLASH GENE
Symbol MED4 contributors: mct - updated : 04-10-2021
HGNC name mediator complex subunit 4
HGNC id 17903
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
interspecies homolog to murine Vdrip
homolog to rattus LOC306030
Homologene
FAMILY
CATEGORY transcription factor , receptor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • plays a role in transcriptional coactivation
  • coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors
  • expression of multiple subunits of the Mediator complex, including MED1, MED4, or MED14, is frequently dysregulated in different types of cancer
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component subunit of the large multiprotein complexes ARC/DRIP and PC2
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inds nuclear receptors in a ligand-dependent manner
  • reduced levels of MED1, MED4, and MED14 perturbed the development of senescence in SSX2-expressing cells
  • cell & other
    REGULATION
    Phosphorylated by CDK11 that is broadly distributed onto chromatin and phosphorylates the MED27 and MED4 Mediator subunits on conserved residues
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS