basic FUNCTION
| mediating signal transduction events that play a role in the regulation of cell development, activation, growth and motility |
|
TSPAN13, TSPAN5 have a reciprocal function during osteoclastogenesis, i.e., positive and negative regulation by TSPAN5 and TSPAN13, respectively |
|
with others TspanC8 tetraspanins have a conserved function in the regulation of ADAM10 trafficking and activity, thereby positively regulating Notch receptor activation |
|
TSPAN5, TSPAN10 play a critical role in osteoclast formation, at least in part, by modulating Notch signaling pathway |
|
functions as a tumour suppressor in stomach to control the tumour growth |
|
TSPAN5 and TSPAN14 can compensate for each other in Notch signaling |