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FLASH GENE
Symbol TSPAN5 contributors: mct - updated : 20-06-2018
HGNC name tetraspanin 5
HGNC id 17753
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • four hydrophobic transmembrane (TM) domains
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Tm4sf9
    homolog to rattus LOC362048
    Homologene
    FAMILY
  • transmembrane 4 superfamily
  • tetraspanin (TM4SF) family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating signal transduction events that play a role in the regulation of cell development, activation, growth and motility
  • TSPAN13, TSPAN5 have a reciprocal function during osteoclastogenesis, i.e., positive and negative regulation by TSPAN5 and TSPAN13, respectively
  • with others TspanC8 tetraspanins have a conserved function in the regulation of ADAM10 trafficking and activity, thereby positively regulating Notch receptor activation
  • TSPAN5, TSPAN10 play a critical role in osteoclast formation, at least in part, by modulating Notch signaling pathway
  • functions as a tumour suppressor in stomach to control the tumour growth
  • TSPAN5 and TSPAN14 can compensate for each other in Notch signaling
  • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TSPAN5 and TSPAN14 positively regulated ligand-induced ADAM10-dependent NOTCH1 signaling
  • endothelial TSPAN5- and TSPAN17-ADAM10 complexes may regulate inflammation by maintaining normal CDH5 expression and promoting T lymphocyte transmigration
  • TSPANC8s are required for ADAM10 trafficking from the endoplasmic reticulum and its enzymatic maturation
  • ADAM10 associates directly with all members (TSPAN5, TSPAN10, TSPAN14, TSPAN15, TSPAN17 and TSPAN33) of a subgroup of tetraspanins having eight cysteines in the large extracellular domain and referred to as TSPANC8
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased in tubal pregnancy than that in intrauterine pregnancy and non-pregnancy
    tumoral     --low  
    in gastric cancer (GC) and closely associated with clinicopathological features including tumour size and TNM stage
    constitutional       gain of function
    TSPAN5 and TSPAN10, are up-regulated during osteoclast differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a prognostic biomarker for predicting outcome of GC patients
  • Therapy target
    ANIMAL & CELL MODELS