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FLASH GENE
Symbol AFF3 contributors: mct/npt - updated : 26-05-2021
HGNC name AF4/FMR2 family, member 3
HGNC id 6473
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal homology domain (NHD) is a region of homology shared by the four AFF members
  • proline and serine-rich domain
  • the hallmark ALF domain, which interacts with seven in absentia homolog (SIAH) ubiquitin ligases through the [xPxAxVxPx] degron motif and thus regulates protein degradation mediated by the proteasome pathway
  • a serine-rich transactivation domain
  • a bipartite nuclear localization sequence (NLS)
  • an eight helices C-terminal homology domain (CHD) that mediates homo- or heterodimerization of AFFs
  • HOMOLOGY
    interspecies homolog to murine Laf4
    intraspecies homolog to MLLT2 ( AF4) and FMR2 (nut2), highly
    Homologene
    FAMILY
  • AF4 family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    text
  • localize to nuclear speckles
  • basic FUNCTION
  • lymphoid nuclear transcriptional activator with DNA-binding capacity and transcription transactivation potential
  • able to bind RNA, having a high apparent affinity for the G-quadruplex structure
  • possible functional redundancy among the AFF family members in the regulation of splicing and transcription
  • functional redundancy for AFF2/AFF3/AFF4 proteins during brain development
  • is one of the targets of the WNT/CTNNB1 pathway, an important contributor to pathways involved in bone development and homeostasis
  • is enriched at gamete differentially methylated regions (DMRs) of the imprinted loci and regulates the imprinted gene expression
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text oncogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interact with the positive transcription elongation factor b (CCNT1)
  • ZFP281 is a critical factor generally associating with AFF3 at enhancers and functioning together with AFF3 in regulating the expression of a subset of genes
  • bind to the DMR downstream of the XIST promoter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) KINSSHIP
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with MLL in t(2;11)(p15;p14) in ALL
    tumoral fusion      
    5'AFF3/3'BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma (Impera 2008)
    constitutional   deletion    
    interstitial microdeletion in Nievergelt sndrome (Steichen-Gersdorf 2008)
    tumoral fusion      
    with RUNX1, partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) (Chinen 2008)
    Susceptibility to rheumatoid arthritis (RA)
    Variant & Polymorphism other association of the AFF3 locus with RA susceptibility (Barton 2009)
    Candidate gene for specific changes of the tibia
    Marker
    Therapy target
    ANIMAL & CELL MODELS